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Volume-12 (2013);
Issue 1 (Jan-Mar)
Published on Apr 15, 2013
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2013;1:1
Review |
Ranjbar S, Pai NB, Deng C.
The Association of Antidepressant Medication and Body Weight Gain. |
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Abstract: Objective: To review the literature and discover which antidepressants are responsible for weight gain and then to discuss the areas with lack of adequate knowledge. Method: An electronic search was conducted through Medline, Pubmed, Cochrane library, and ScienceDirect. Forty nine empirical researches were identified and reviewed. Results: Amitriptyline, clomipramine, and mirtazapine have been associated with more weight gain induction in clinical studies, but not in animal-based studies. All TCAs have been reported to cause weight gain except protriptyline. MAOIs have been associated with weight gain. In SSRI group, citalopram and ecitalopram induce weight, yet mixed results exist for paroxetine and fluoxetine. Researches unanimously reported weight loss effect for bupropion. Some studies suggest contributing factors in the relationship of antidepressants with body weight changes including age, gender, base-line weights and treatment duration. Various results of different treatment durations have been reported in some cases but there are not continuous time-dependent studies for the influences of antidepressants on body weight changes. Conclusion: More studies are required to discover underlying mechanisms and the time-dependent effects of antidepressants on body weight changes.
Key words: Antidepressants; Body weight; Obesity. |
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This Article |
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2013;1:2
Original Article |
Mullah F, Kumar D, Antani D, Gupta M.
Study of Knowledge, Perceptions and Practices Related to Blood Donation Among the Healthcare Support Staff of a Tertiary Care Hospital in Gujarat, India. |
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Abstract: Background: There is a serious mismatch between demand and availability of blood in our country. One of the important factors motivating people for donating blood is their interaction with staff of health facilities including support staff. The knowledge and perceptions of support staff about blood donation have not been studied adequately. Methodology: Data was collected from randomly selected 100healthcare support staff using a pretested questionnaire. The questionnaire was based on prior qualitative analysis of perceptions of few of the potential participants. Results: 91% of the respondents felt that blood donation was not safe. Only 16% had adequate knowledge about eligibility for blood donation and all of them were females. 39% respondents had donated blood themselves and 79% had family history of blood donation. None of the socio-demographic factors except young age were found to be associated with better knowledge or positive perceptions about blood donation. Many among those who had donated blood also did not perceive blood donation as safe. Apprehension about blood being not properly used and not having been approached by anyone were commonest reasons for not donating. Conclusions: The knowledge about safety, eligibility and motivation for blood donation is very poor among the healthcare support staff. Efforts must be made to educate these employees and promote voluntary blood donation among them. Various incentives as suggested by employees themselves and several international bodies may be considered to promote blood donation among healthcare support staff.
Key words: Voluntary blood donation; Hospital employees; Healthcare support staff. |
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This Article |
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2013;1-3
Original Article |
Aruna G, Yadiyal MB.
Is Electroconvulsive Therapy Fading into Oblivion?: A Study of Ten Year Trends. |
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Abstract: Background: Despite proven efficacy, modified ECT has been variably used in the recent past, with data on the usage trend being scarce, worldwide. Aim: We aimed to do a time – series analysis to examine annual trends in modified ECT use in our tertiary teaching hospital in the last decade. Methods: A chart review was carried out on all patients who received m-ECT in our teaching hospital in the last ten years (2002 to 2011), and percentage of total inpatients receiving M-ECT each year was deduced. Along with number of ECT sessions given per year, details of demographic data, and indications for ECT were recorded. Results: In our study ECT was undersized as a treatment option, with only 1:13% of total inpatients having received ECT. Also it was noted that use began increasing from 2002, reaching a peak in 2006 (84% increase) followed by a downward trend, with a sharp decline since 2008 (61%decrease) and finally reaching a nadir in 2011 (69% decrease). Mean age of patients ranged from 31.28 to 40.1 years with a slightly high female preponderance in most year groups. The most common indication for ECT use was schizophrenia (47.8%) followed by, depression (38.9%). Conclusion: Although, our study finding is in line with the downward trend of ECT utilization rates reported worldwide, the nature and magnitude of decline cannot be explained nor compared globally due to variations, inaccuracies and heterogeneity of ECT data currently available. Further, factors responsible for such trends should become focus of future research.
Key words: Modified Electroconvulsive Therapy; Utilization; Trends |
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This Article |
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2013;1-4
Case Report |
Krishnanand, Chanchalani R, Dhruv K.
Rapunzel Syndrome: Trichobezoar in a 13 Years Old Girl. |
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Abstract: Background: Rapunzel syndrome is a rare type of trichobezoar with an extension of the hair into the small bowel. Clinical presentation is deceptive and vague ranging from abdominal mass to gastrointestinal symptoms.
Case Presentation: We present a 13 years old girl with Rapunzel syndrome, where the trichobezoar was not suspected at all especially with negative history of trichophagia. In majority of the cases the diagnosis was made very late in the history of the disease, at a stage where surgery is the only cure for this syndrome. Conclusion: A trichobezoar represents a serious surgical condition. It is important to consider such diagnosis in face of suggestive symptoms, even if signs of trichotillomania are not present. The discrepancies between the prevalence of trichotillomania and trichobezoars due to trichophagia may be due to issues related to self-selection of patients and symptom severity. Such issues may also be important in the study of impulsive-compulsive spectrum models and to their relevance to impulse control disorders.
Key words: Rapunzel syndrome; Trichobezoar |
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This Article |
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2013;1-5
Case Report |
Kaushik M, Mahajan S, Raina R, Babu S, Raghav S, Sood S, Guleria R.
Isolated Amoebic Abscess of Spleen. |
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Abstract: Amoebic liver abscess
is the most common extraintestinal manifestation of amoebiasis. Extrahepatic amoebic abscesses have occasionally been
described in the lung, brain, and skin and presumably result from hematogenous spread.Isolated amoebic
abscess of spleen has been reported scarcely in literature. We report here a case of isolated amoebic
abscess of spleen.
Key words: Entamoeba histolytica; Extraintestinal amoebiasis; Splenic abscess; Trophozoites. |
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This Article |
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2013;1-6
Case Report |
Ganju NK, Negi PC, Marwah R.
Intercoronary Continuity: A Rare Variant of Coronary Circulation. |
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Objectives: Coronary circulation if significantly diseased usually develop collaterals between the distal portion of the diseased vessel and the normal artery to accomplish flow in vessel distal to the diseased segment. These collaterals can be intracoronary or intercoronary. Coronary collaterals have to be differentiated from intercoronary continuity, which is a very rare variant of coronary circulation usually seen in angiographically normal looking arteries. In our patient, although proximal left anterior descending artery revealed significant lesion but intercoronary continuity was seen between normal right coronary artery and left circumflex artery on angiography.
Key words: Intercoronary continuity; Collaterals; Angiography
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This Article |
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2013;1-7
Case Report |
Kaushik ML, Mahajan S, Raina R, Kumar B, Tomar A, Marwah R.
Pseudohypoparathyroidism Presenting as Congestive Cardiac Failure. |
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Abstract: Hypocalcaemia can have a variety of manifestations including cardiovascular changes. Hypocalcemic cardiomyopathy has been reported in hypoparathyroidism and vitamin D deficiency but association of hypocalcemic cardiomyopathy in Pseudohypoparathyroidism has been reported scarcely in literature. We describe here a case of PHP presenting as congestive cardiac failure.
Key words: Pseudohypoparathyroidism; Hypocalcaemia; Cardiomyopathy; Vitamin D |
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This Article |
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2013;1-8
Case Report |
Wader J, Kshirsagar A, Gajbi N, Kumbhar S.
Ectopic Prostatic and Seminal Vesicle Tissue Confusing as Metastatic Adenocarcinoma. |
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Abstract: Ectopic prostatic tissue and seminal vesicle at pericolic fat is extremely rare. The nodules in the pericolic fat could raise a dilemma of metastatic deposits in cases of rectal adenocarcinoma. A 61 years old male underwent abdomino-perineal resection for rectal carcinoma. Nodules along with lymph nodes from pericolic fat were sampled to assess the spread. Histopathological and immunohistochemical staining of one nodule confirmed it to be the prostatic tissue while another nodule to be seminal vesicle. Seminal vesicle and prostatic heterotopia is significant in several respects, either symptomatic or asymptomatic, as the ectopic tissue can be endoscopically and histologically confused with malignancy of urinary or lower gastrointestinal system and may reflect divergent differentiation or a malformative process.
Key words: Ectopic prostate; Seminal vesicle; Adenocarcinoma. |
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This Article |
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2013;1-9
Case Report |
Rajeshwari K, Dravid NV, Goyal N, Gadre A, Pawar S, Karibasappa GN.
Adolescent Neuroblastoma of Lower Limb. |
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Abstract: Neuroblastoma is
an embryonic tumour of neural crest origin, commonly seen in children with upper abdomen involvement.
Rarely neuroblastoma present in adolescents and adults involving lower limb. Histopathologically
neuroblastoma of lower limb can be confused with other small round cell tumour especially with
Ewings and rhabdomyosarcoma. A 16 year old male presented with 15x11cm swelling, pain and multiple
discharging sinuses of right leg since 4 months. Routine haematological and biochemical analysis
were within normal limits. Radiology of right leg showed large soft tissue swelling encompassing
the pathological fracture tibia of and bowing of fibula. Fine needle aspiration of the swelling
revealed malignant small round cell tumour. Histopathology revealed poorly differentiated
neuroblastoma of lower limb.The immunohistochemistry of Synaptophysin and Chromogranin were
positive and CD 99 was negative. Neuroblastoma diagnosed at unusual site with uncommon age has poor prognosis. Hence one must keep in mind the differential diagnosis of neuroblastoma as one of the differential diagnosis in evaluating the soft tissue tumours of lower limb.
Key words: Neuroblastoma; Adolescent; Lower limb. |
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This Article |
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2013;1-10
Case Report |
Raphael V, Das H, Khonglah Y, Sarma R, Topno N.
Mixed Mucinous Carcinoma of the Male Breast. |
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Abstract: Male breast pregnancy is extremely rare, representing less than 1% of all breast carcinomas. Infiltrating duct carcinoma is the commonest subtype. Pure mucinous carcinoma and mixed mucinous carcinoma wherein there are components of both mucinous carcinoma and infiltrating duct carcinoma are rare tumours constituting 1.5-5% in women and are even rarer in men. We present here a case of mixed mucinous carcinoma of the breast with metastasis to axillary lymph nodes in a male patient.
Key words: Male breast carcinoma; Mixed mucinous carcinoma |
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This Article |
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2013;1-11
Case Report |
Patil RN, Reshme N, Kundargi R.
Perineal Aggressive Angiomyxoma: A Rare Presentation. |
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Abstract: Aggressive Angiomyxoma(AA) is defined as benign neoplasm but has infiltrative potential into skeletal muscle and fat. AggressiveAngiomyxoma is a rare neoplasm with about 150 reported cases so far. It is most often found in women in reproductive age with a peak incidence in the fourth decade of life. Aggressive Angiomyxoma is most often found in or in proximity to the lower pelvis, more specifically perineum, vulva, vagina or inguinal regions. Most AA are big, often more than 10 cm in largest diameter.. Radical surgery with wide margins is the treatment of choice .The prognosis is very good.here .Because of its rarity and unique presentation we are reporting a case of a huge perineal AA in a 42 year female which presented as a tumour coming out of the breach in skin. She underwent surgery, wide local excision and after 7 months follow-up is free of tumor.
Key words: Aggressive angiomyxoma; Vulva; Benign; Surgery |
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This Article |
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2013;1-12
Case Report |
Kumar S, Diwan SK.
Spontaneous Bacterial Peritonitis Presenting as Acute Abdomen in a Patient with Chronic Kidney Disease. |
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Abstract: Spontaneous bacterial peritonitis (SBP) is a relatively common problem in adult patients with liver cirrhosis. The complication of SBP in adults with chronic kidney disease on maintenance hemodialysis is, however, extremely rare. To best of our knowledge this is probably the first case report.
Key words: Spontaneous bacterial peritonitis; Chronic kidney disease; Acute abdomen. |
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This Article |
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2013;1-13
Case Report |
Ankegowda ST, Surhonne SP, Kenchappa S, Raymane AP.
Littoral Cell Angioma of Spleen: A Rare Cause of Sudden Mysterious Death.
This paper is removed following a complaint of plagiarism. Many sentences under the sections Introduction
and Discussion are found to be Copy-Pasted directly from their sources, many of them uncited. |
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Abstract: Littoral cell angioma is a recently described primary vascular neoplasm of the spleen. It originates from the cells lining the venous sinuses (littoral cells) of the normal spleen, which under yet unexplained stimuli, proliferate to form the characteristic lesions seen grossly. We report a case of Littoral cell angioma of spleen in a 57 year old man, an incidental autopsy finding which led to mysterious death.
Key words: Littoral cell angioma; Vascular neoplasm; Littoral cells. |
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2013;1-14
Case Report |
Challa VR, Krishnamurthy S, Goud BYG, Poornima.
Sacral Chordoma and Single Stage Combined Anteroposterior High Sacrectomy. |
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Abstract: Chordomas are locally aggressive tumors, most commonly seen in sacrum. We present a case of sacral chordoma who presented with urinary retention and treated with single stage combined anteroposterior high sacrectomy
Key words: Chordoma; Urinary retention; Anteroposterior High Sacrectomy. |
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This Article |
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2013;1-15
Case Report |
Wader JV, Kumbhar SS, Huddedar AD, Khatib WGM.
Chromophobe Renal Cell Carcinoma. |
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Abstract: Renal cell carcinoma is the
most common neoplasm of the kidney comprised of different histological variants. Chromophobe renal cell
carcinoma (ChRCC) is a rare subtype of renal cell carcinoma (RCC) mainly diagnosed in the sixth decade of life.
It is important to identify this entity because it has significantly better prognosis than the clear cell
(conventional) and papillary renal cell carcinomas. The chromophobe renal cell carcinoma should be
differentiated from oncocytoma and clear cell carcinoma. We report a case of a 70 year-old male who
presented with a six month history of hematuria, left sided flank pain and a palpable non-tender lump in
the left lumbar region. On radiology, the possibility of a left renal neoplasm was raised. A left radical
nephrectomy was done and histopathological diagnosis of Type 2 (mixed) chromophobe renal cell carcinoma
was given. We present this case owing to its relative rarity of incidence, difficulties encountered
and differential diagnoses to be considered during diagnosis as the prognosis and management protocols
differ with different variants.
Key words: Chromophobe renal cell carcinoma; Type 2 mixed variant. |
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